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Biology

  • Jesus Angulo, Ph.D. Professor of Biology, Hunter College angulo@genectr.hunter.cuny.edu

    Research Interest: Neuropeptide Regulation and Function in Nigrostriatal and mesolimbic pathways.

    My research focuses on clarifying thecellular and molecular mechanisms by which some neuropeptides mediate long-term adaptations to offset the damaging impact resulting from chronic exposure to psychostimulant drugs such as cocaine and amphetamines.

  • Jill Bargonetti, Ph.D. Professor of Biology, Hunter College bargonetti@genectr.hunter.cuny.edu

    Research Interest:DNA damage signaling to p53 and Mdm2

    Jill Bargonetti and her laboratory group are currently working to determine if DNA damage caused by various chemotherapeutic drugs (alone and in combination) are able to bring about differential activation of the p53 target genes as well as activate alternative cell death pathways. Mitomycin C (MC) and 10-decarbamoyl MC (DMC) signal to the p53 pathway and other pathways.

  • Derrick Brazill, Ph.D. Associate Professor of Biology, Hunter College brazill@genectr.hunter.cuny.edu

    Research Interest:Extracellular Factors Regulating Cell Behavior

    Proteins in human serum constantly bombard our cells with numerous signals, telling them to grow, multiply, differentiate or die.  These signals must be properly integrated by the cells in order to ensure the health of the individual.  Loss of regulation can lead to defects and diseases including metastatic cancer and atherosclerosis.  Our lab is specifically interested in how these signals regulate the cytoskeleton.

  • Laurel Eckhardt, Ph.D. Hesselbach Professor of Biology, Hunter College eckhardt@genectr.hunter.cuny.edu

    Research Interest:Molecular Genetics of Lymphocyte Development and Differentiation.

    The current major research interest of the laboratory is the control of antibody (or immunoglobulin) gene expression in the developing B lymphocyte. We and others have identified multiple transcriptional enhancers within the immunoglobulin heavy chain (IgH) locus. IgH gene assembly, transcription, heavy chain class-switching, and even the malignant transformation of the Ig-secreting cell likely depend upon the action of one or more of these enhancers. We are undertaking functional analyses of the enhancers (using transgenic mice and Igh locus-modified mice) to identify their respective roles in the complex regulation of this immunologically important locus.

  • Benjamin Ortiz, Ph.D. Associate Professor of Biology ortiz@genectr.hunter.cuny.edu

    Research Interest:Gene regulation and genetic engineering of T cells

    Our laboratory investigates gene regulation during T cell development.  We use both in vivo transgenic mouse models as well as newly developed technology for in vitro T cell development from embryonic stem cells.  Our focus has been on the regulation of the gene locus encoding the alpha chain of the T cell receptor (TCRa), particularly its locus control region (LCR).

  • Weigang Qiu, Ph.D. Associate Professor of Biology weigang@genectr.hunter.cuny.edu

    Research Interests: Biological Questions. I am interested in the population genomics of microbial species. The main focus of my lab is the comparative analysis of multiple genomes of the Lyme disease pathogen. The goals of my research include reconstructing the history of worldwide diversification of the Lyme disease bacteria, an understanding of the mechanisms of their genome evolution (e.g., the roles of recombination and natural selection), and inference of gene and genome functions.

    My Research Approach is bioinformatics, and more specifically, the computational and statistical testing of evolutionary hypotheses. Students learn and use modern computational tools such as relational database/SQL, Perl/BioPerl, and statistical computing with R.

  • Patricia Rockwell, Ph.D. Associate Professor of Biology rockwell@genectr.hunter.cuny.edu

    Research Interest:Signal Transduction Pathways

    Our research focuses specifically on identifying the signaling intermediates underlying the neuroprotection that VEGF mediates through activation of its cognate receptor VEGFR-2 in both in vitro and in vivo model systems of neuronal cell stress. We have identified signaling pathways that VEGF modulates to promote cell survival and those that VEGF suppresses to prevent cell death. The rationale for these studies is to determine whether VEGF would serve as a useful therapeutic to prevent the neuronal cell damage associated with neurodegenerative disorders.

  • Hualin Zhong, Ph.D. Assistant Professor of Biology zhong@genectr.hunter.cuny.edu

    Research Interest:Regulation of gene expression and nuclear transport

    The nuclear pore complexes (NPCs) are multiprotein assemblies embedded in the nuclear envelope and play a critical role in regulating essential cellular events including replication, transcription, translation and DNA repair by controlling transport of macromolecules into and out of the nucleus. Each NPC contains about 30 different proteins, which are collectively called nucleoporins (Nups).